CellWell record HH-465358
Levonorgestrel-ethinyl estradiol impairs hepatic lipid clearance to induce hypercholesterolemia via PCSK9-mediated LDLR and CD36 dysregulation.
Bing-Zhi Li; Chen-Ji Ye; Zhuo Wang; Jun-Ying Zhang; Ze-Yu Fan; Ying-Hui Huo; Xian-Wei Wang; Feng-Hua Lv
Toxicology and Applied Pharmacology ยท 2026
In plain language
In female mice, an oral contraceptive combination raised PCSK9, lowered liver LDL receptor, and increased LDL cholesterol and triglycerides, while these changes were absent in mice lacking PCSK9.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-465358
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