CellWell record HH-465306
The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion
Grigorios Panteloglou; Jérôme Robert; Marieke Smit; Nicolette Huijkman; Niels Kloosterhuis; Christopher S. Law; Brian Woods; Alaa Othman; Marcus Edi Kleber; Graciela Delgado; Patrizia Tarugi; Museer A. Lone
Atherosclerosis · 2026
In plain language
Silencing COPI coatomer genes in liver cells reduced LDL uptake and surface LDL receptor and raised apoB secretion, and Copg1 knockdown raised non-HDL cholesterol in mice, with some rare human COPI variants linked to higher LDL-C.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-465306
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