Studies

CellWell record HH-46461

A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications

Raunak Khanduja; Richard E Frye

2026

In plain language

This systematic review of 159 studies found the gut microbiome both produces and consumes folate, with altered microbial folate metabolism linked to metabolic, neuropsychiatric and other disorders, and probiotics showing the strongest evidence.

Evidence
Established
Design
Systematic review

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