CellWell record HH-464216
High TG/low HDL-C ratio -- mimetic lipid stress drives diabetic atherosclerotic endothelial -- macrophage dysfunction through glycocalyx disruption and CD36/ABCA1 imbalance
Le-Chang Bi; Wen Zhao; Ming-Jing Lu; Nan Jiang; Gao-Feng Wang; Fei-Lai Huang; Peng-Chao Luo; Guo-Fu Wang
Journal of Molecular Histology ยท 2026
In plain language
In cultured human coronary endothelial cells, lipid stress mimicking a high triglyceride/low HDL ratio disrupted the glycocalyx and promoted inflammation, and heparanase inhibition preserved glycocalyx integrity.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-464216
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