CellWell record HH-462483
Loss of Proximal Tubule Lactate Dehydrogenase A (LDHA) Exacerbates Nephrotoxic Acute Kidney Injury Through Metabolic Dysregulation
Yan Lu; Anna A Zmijewska; Yanfeng Zhang; Gunars Osis; M. D. Cheung; L. Wilson; Yanlin Jiang; Sudeepthi Vejendla; A. Traylor; Stephen Barnes; James F. George; Anupam Agarwal
AJP - Renal Physiology ยท 2026
In plain language
In mice, deleting lactate dehydrogenase A from proximal tubules worsened cisplatin-induced kidney injury and altered purine, nucleotide, and energy metabolism.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-462483
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