CellWell record HH-457641
From Radiocopper to Cold Copper: Mechanistic Modeling and Simulation to Define Clinical Response Criteria and Biomarkers for VTX-801 in Wilson Disease
Andreas Lindauer; Bernard Benichou; Gloria González Aseguinolaza; Jean-Philippe Combal
2026
In plain language
A mechanistic copper-metabolism model simulated Wilson disease and suggested that relative exchangeable copper could serve as a simpler non-radioactive biomarker of restored ATP7B function, alongside a plasma radiocopper ratio distinguishing responders.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-457641
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