CellWell record HH-453702
Thyroid Hormone Synthesis Without Thyroglobulin
Crystal Young; Xiaohan Zhang; Aaron P. Kellogg; Tatiana L. Fonseca; Kevin Pena; Alisa Beyzin; Xiao-Hui Liao; Annunziata G. Cicatiello; Hao Zhang; Antonio C. Bianco; Samuel Refetoff; Peter Arvan
Thyroid® · 2026
In plain language
In mice lacking thyroglobulin entirely, circulating T4 eventually normalized as goiter enlarged, with T3 near two-thirds of normal, because T4-containing protein formed on the remains of dead thyrocytes.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-453702
Produced by the CellWell Research Engine, custom software owned and operated by CellWell. All rights reserved. This analysis, its indexing and its evidence classifications are proprietary. Any use, republication or onward sharing must credit CellWell Research Engine (thecellwell.org) as the source.
This is an educational research library, not medical advice. Nothing here may be used to diagnose, treat, cure, or prevent any disease. Always consult a qualified professional.