Studies

CellWell record HH-441143

Efficacy and effectiveness of melatonin for the management of musculoskeletal pain: a systematic review and meta-analysis of placebo and active controlled trials

Kangchao Wu; Ting Him Ho; Paula R Beckenkamp; Michelle Hall; Hanzhi Zhang; James Puterflam; Karin Due Bruun; Jianhua Lin; Christopher Gordon; Ron Grunstein; Manuela L Ferreira; Paulo Ferreira

2026

In plain language

In 23 randomized trials, melatonin was not superior to placebo for chronic musculoskeletal pain but outperformed active comparators, with low-to-moderate certainty evidence.

Evidence
Established
Design
Meta-analysis

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