CellWell record HH-436738
Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity
Alan Y L Wong; Jacob W Myers; Gyan Prakash; Alice Ma; Jeannette R Brook; Boryana Petrova; Baran Bulut; Ralph White; Catherine Merz; Maeve de Souza; Adam G Maynard; Peng Wang; Amy Yu; Nancy K Pohl; Michal Weitman; Lewis B Silverman; Kimberly Stegmaier; L Stirling Churchman; Peter D Cole; Donita C Brady; Naama Kanarek
2026
In plain language
In mouse models of human leukemia, reducing copper, either by deleting the SLC31A1 transporter or through diet, slowed growth of systemic and central nervous system acute lymphoblastic leukemia.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-436738
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