CellWell record HH-425458
Association of metformin use with vitamin B12 deficiency and peripheral neuropathy in type 2 diabetes mellitus: a systematic review and meta-analysis
Noura Mohammed; Awad Sirelkhatim Osman Taha; Noura MohamedSalih; Mishaal Mohammed; Thoiba Rahama; Nadir Abdelrahman; Maha Osman Abdullah Idris; Nafisa Saeed; Noon Abdalazeem Abbas Mustafa
BMC Endocrine Disorders ยท 2026
In plain language
In people with type 2 diabetes, metformin use and vitamin B12 deficiency were each associated with higher peripheral neuropathy risk, and about one-third of metformin-treated patients were B12 deficient in this meta-analysis of twenty studies.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-425458
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