CellWell record HH-42093
Oxidative Stress in Keratoconus Is Evident in Tear Fluid and Stromal Cells and Alleviated in Cell Culture by Sulforaphane
Madhuri A Koduri; Mackenzie Charter; Rohini Sonar; Rashmi Deshmukh; Christina R Prescott; Rose Mandel; Laurence Sperber; Ting-Fang Lee; Elias H Kahan; Ilyse D Haberman; Vivek Singh; Andrea L Blitzer; George Maiti; Shukti Chakravarti
2026
In plain language
In cultured human keratoconus stromal cells, impaired NRF2 antioxidant signaling was linked to increased apoptosis under oxidative stress, an effect reduced by the compound sulforaphane, while patient tear fluid showed elevated oxidative markers MDA and GPX3 versus controls.
- Evidence
- Emerging
- Design
- Cell-culture study
Cite this record: https://thecellwell.org/studies/HH-42093
Produced by the CellWell Research Engine, custom software owned and operated by CellWell and The Holistic Hub. All rights reserved. This analysis, its indexing and its evidence classifications are proprietary. Any use, republication or onward sharing must credit CellWell Research Engine (thecellwell.org) as the source.
This is an educational research library, not medical advice. Nothing here may be used to diagnose, treat, cure, or prevent any disease. Always consult a qualified professional.