CellWell record HH-41276
Effect of green mediterranean diet on serum folate and its interaction with genetic variation in folate metabolism: The DIRECT PLUS 18-month dietary randomized controlled trial
Zelicha H; Keller M; Meir AY; Rinott E; Tsaban G; Kaplan A; Hoffmann A; Blüher M; Ceglarek U; Isermann B; Stumvoll M; Shelef I; Hu FB; Stampfer MJ; Kovacs P; Shai I
Clinical nutrition (Edinburgh, Scotland) · 2026
In plain language
In the 294-participant DIRECT PLUS trial, an 18-month green Mediterranean diet enriched with a plant shake raised serum folate more than a standard Mediterranean or healthy diet, most in carriers of the MTHFR CC and CT genotypes.
- Evidence
- Established
- Design
- Randomized controlled trial
Cite this record: https://thecellwell.org/studies/HH-41276
Produced by the CellWell Research Engine, custom software owned and operated by CellWell and The Holistic Hub. All rights reserved. This analysis, its indexing and its evidence classifications are proprietary. Any use, republication or onward sharing must credit CellWell Research Engine (thecellwell.org) as the source.
This is an educational research library, not medical advice. Nothing here may be used to diagnose, treat, cure, or prevent any disease. Always consult a qualified professional.