CellWell record HH-40554
Targeting a Shared Mitophagy Regulator: The SIRT1-FOXO3-DEPP1 Axis Underpins the Dual Bone and Brain Benefits of Total Flavonoids from Drynaria fortunei
Yili Zhang; Xiangyun Guo; Qing Wang; Long Xiao; Qingqing Liu; Yiwen Gan; Yunning Li; Chuanrui Sun; Zhiwen Luo; Kai Sun; Weiwei Tao; Xu Wei
2026
In plain language
In menopausal and stressed mice and in cultured bone and brain cells, flavonoids from Drynaria fortunei preserved bone density and reduced depression-like behavior, an effect that required SIRT1-FOXO3-DEPP1 signaling.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-40554
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