CellWell record HH-38097
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity
Umansky C; Morellato AE; Rieckher M; Scheidegger MA; Martinefski MR; Fernández GA; Pak O; Kolesnikova K; Reingruber H; Bollini M; Crossan GP; Sommer N; Monge ME; Schumacher B; Pontel LB
Nature communications · 2022
In plain language
In human cells and in the worm C. elegans, endogenous formaldehyde reacted directly with glutathione's active thiol group, disrupting the cell's redox balance and causing toxicity, an effect blocked by boosting glutathione synthesis and eased by thiol-rich antioxidants like N-acetylcysteine.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-38097
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