Studies

CellWell record HH-371609

Serum trimethylamine N-oxide and choline, and risk of cardiovascular events and mortality in 14 countries: a case-cohort analysis from the Prospective Urban and Rural Epidemiology (PURE) study

F. Mannan; M. Pigeyre; V. Miller; Z. Kroezen; M. Shanmuganathan; P. Britz-Mckibbin; S. Rangarajan; S. Yusuf; G. Paré

European Journal of Preventive Cardiology · 2026

In plain language

In 9,287 participants from 14 countries, serum and urinary TMAO were not independently associated with cardiovascular events, mortality or diabetes, while serum choline showed a modest positive association with cardiovascular events.

Evidence
Emerging
Design
Primary research (design unspecified)

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