CellWell record HH-347348
Intestinal lipase inhibition uncouples diet-induced obesity from MASH by remodeling the hepatic lipidome in mice
Alvin P Chan; Tomasz J Czernuszewicz; Rochelle W Lai; Kelsey E Jarrett; Andrew Lau; Anisa Warshan; Angela S Cheng; Michelle E Steel; Heidi M Schmidt; Jakeline Larios; Isaiah Little; Gabriella E Rubert; Madelaine C Brearley-Sholto; Zeinab Mamouei; Jessica K Pesner; Christopher D Hamad; Kevin P Francis; Nicholas M Bernthal; Elizabeth F Redente; Clara E Magyar; Samual W French; Kevin J Williams; Elizabeth J Tarling; Thomas Q de Aguiar Vallim
2026
In plain language
Intestinal lipase inhibition with orlistat uncoupled obesity prevention from MASH by depleting essential polyunsaturated fatty acids, thereby exacerbating liver inflammation in mice.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-347348
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