CellWell record HH-3473
Physiological functions of thioredoxin and thioredoxin reductase
Arner ESJ, Holmgren A
European Journal of Biochemistry ยท 2000
In plain language
Replacing thioredoxin reductase's selenocysteine with ordinary cysteine collapses its catalytic activity to about 1%, demonstrating that the selenium atom itself -- not just the protein scaffold -- performs the antioxidant catalysis.
- Evidence
- Established
- Design
- Cell-culture study
- Studied in
- Cell / in vitro
Cite this record: https://thecellwell.org/studies/HH-3473
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