CellWell record HH-332593
A mathematical model of folate-mediated one-carbon metabolism in Down syndrome.
A. Piovesan; Diletta Poluzzi; G. Ramacieri; C. Locatelli; F. Antonaros; B. Vione; M. Caracausi; Maria Chiara Pelleri; L. Marchetti
npj Systems Biology and Applications ยท 2026
In plain language
Mathematical modeling identified formate-tetrahydrofolate ligase as a key enzyme altered in simulated Down syndrome folate metabolism, with correlation to chromosome-21-encoded GART overexpression.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-332593
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