CellWell record HH-330747
The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice
Jun Nakamura; Darcy W. Holley; Toshihiro Kawamoto; Scott J. Bultman
Genes and Environment ยท 2020
In plain language
Mice deficient in both ADH5 and ALDH2 formaldehyde-metabolizing enzymes showed partial synthetic lethality with decreased post-natal survival and 37% reduced body weight.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-330747
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