CellWell record HH-328891
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans
Felix A. Dingler; Meng Wang; Anfeng Mu; Christopher L. Millington; Nina Oberbeck; Sam Watcham; Lucas B. Pontel; Ashley N. Kamimae-Lanning; Frédéric Langevin; Camille Nadler; Rebecca L. Cordell; P. S. Monks
Molecular Cell · 2020
In plain language
Mice deficient in formaldehyde-clearing enzymes develop leukemia with elevated blood formaldehyde and DNA adducts, implicating endogenous formaldehyde in hematopoietic toxicity.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-328891
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