CellWell record HH-32648
Benzalkonium chlorides compromise oocyte maturation and developmental competence by disrupting mitochondrial function and the SIRT3-SOD2 antioxidant axis
Khienduc Lay; Dandan Zhang; Hui Wang; Mengchan Li; Yongteng Zhang; Qimei Xu; Bo Jia; ThiHien Nguyen; Chunhuan Ren; Xiaoyan Zhou; Heng Tang; Yinghui Ling; Mengting Wu; Yang Gao; Mianqun Zhang; Yunhai Zhang
2026
In plain language
In cultured pig egg cells, benzalkonium chloride disinfectant exposure impaired maturation and fertilization in a dose-dependent way by damaging mitochondria and disrupting an antioxidant pathway called SIRT3-SOD2, with partial recovery when reactivated.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-32648
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