CellWell record HH-32419
Polymorphisms in CLAUDIN1 and SPINK5 Influence Skin Absorption of Pyrene, Pyrimethanil, and Oxybenzone in Human Volunteers
Keysendal E; Johanson G; Hagvall L; Fyhrqvist N; Lindh C; Broberg K; Liljedahl ER
Environmental and molecular mutagenesis ยท 2026
In plain language
In 54 human volunteers, a gene variant in CLAUDIN1 was linked to faster and greater skin absorption of pyrene, a fungicide and the sunscreen chemical oxybenzone, though filaggrin gene status remained the strongest predictor of chemical uptake through skin.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-32419
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