CellWell record HH-304144
Antioxidant malic-acid-derived lipid nanoparticles delivering secretory uricase circRNA for hyperuricemia and complication management in mice
Du K; Guo Y; Zhou J; Liu Y; Jiang L; Hua D; Zhang D; Zhang Y; Deng Z; Zheng X; Guo J; Ni J; Li Y; Sun S; Lin Z; Huang J; Wu LP
Nature communications ยท 2026
In plain language
In mouse models of hyperuricemia, malic-acid-derived lipid nanoparticles delivering circular RNA encoding secretory uricase produced sustained urate reduction, less tissue inflammation and fibrosis, reduced arthritic pain, and preserved kidney function.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-304144
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