CellWell record HH-26327
Quantitative in vitro to in vivo extrapolation (QIVIVE) of atrazine's effects on phosphodiesterase and aromatase mRNA expression in vitro to the rat in vivo based on pharmacokinetic
James W Simpkins; Ralph L Cooper; Charles Breckenridge
2026
In plain language
In steroidogenic cell lines, 10 micromolar atrazine raised aromatase mRNA two to three fold, but modelling showed those concentrations are 350 to 1,013 times higher than plasma levels at regulatory exposure points.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-26327
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