Studies

CellWell record HH-237251

Lipoprotein(a) in cardiovascular disease: pathophysiology, residual risk, and emerging therapeutic strategies

Lucio Giuseppe Granata; Simona Giubilato; Francesca Campanella; Francesco Amico; Stefania Angela Di Fusco; Furio Colivicchi

2026

In plain language

Lipoprotein(a) is a genetically determined risk factor for atherosclerotic cardiovascular disease unresponsive to lifestyle and poorly controlled by statins, but RNA therapeutics targeting hepatic LPA expression reduce levels by 80-90%.

Evidence
Emerging
Design
Expert review

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