CellWell record HH-21438
Metabolomic Profiling of Tyrosine Kinase Inhibitor-Induced Endothelial Dysfunction and Cardiovascular Toxicity
Gurkaranvir Singh; Inderjeet Bharaj; Joey Bettencourt; Amarjit Kaur Sekhon; Gurparvesh Singh; Aaron Sidhu; Emanuel Zayas Diaz; Sulaiman Paika; Ariel De Leon; Ajit Brar; Gursimran Brar; Inderbir Padda; Ambar Andrade
2026
In plain language
In metabolomic analyses across several tyrosine kinase inhibitors, convergent signatures appeared as mitochondrial bioenergetic dysfunction with impaired long-chain fatty acid oxidation and adenylate depletion, plus endothelial disruption.
- Evidence
- Emerging
- Design
- Expert review
Cite this record: https://thecellwell.org/studies/HH-21438
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