Studies

CellWell record HH-203465

Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

Orion S Willoughby; Anna S Nichenko; Matthew H Brisendine; Niloufar Amiri; Shelby N Henry; Daniel S Braxton; John R Brown; Braeden J Kraft; Kalyn S Jenkins; Adele K Addington; Alexey V Zaitsev; Steven T Burrows; Ryan P McMillan; Haiyan Zhang; Spencer A Tye; Charles P Najt; Siobhan E Craige; Timothy W Rhoads; Junco S Warren; Joshua C Drake

2026

In plain language

Ulk1 S555 phosphorylation by AMPK maintains metabolic flexibility during caloric restriction; its loss impairs glucose oxidation and shifts metabolism toward amino acids.

Evidence
Emerging
Design
Primary research (design unspecified)

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