CellWell record HH-20122
Early life stress and the pathogenesis of visceral hypersensitivity: mechanisms and implications for disorders of gut-brain interaction
Enfu Tao
2026
In plain language
This narrative review proposes early life stress produces persistent visceral hypersensitivity in irritable bowel syndrome through HPA axis and epigenetic changes in limbic circuits, spinal BDNF and potassium channel changes, and peripheral mast cell and microbiota alterations.
- Evidence
- Emerging
- Design
- Expert review
Cite this record: https://thecellwell.org/studies/HH-20122
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