CellWell record HH-20099
A microbiome-dependent gut-brain pathway regulates motivation for exercise
Dohnalová L; Lundgren P; Carty JRE; Goldstein N; Wenski SL; Nanudorn P; Thiengmag S; Huang KP; Litichevskiy L; Descamps HC; Chellappa K; Glassman A; Kessler S; Kim J; Cox TO; Dmitrieva-Posocco O; Wong AC; Allman EL; Ghosh S; Sharma N; Sengupta K; Cornes B; Dean N; Churchill GA; Khurana TS; Sellmyer MA; FitzGerald GA; Patterson AD; Baur JA; Alhadeff AL; Helfrich EJN; Levy M; Betley JN; Thaiss CA
Nature · 2022
In plain language
In mice, gut microbiome-derived endocannabinoid-like metabolites activated TRPV1-expressing sensory neurons and raised striatal dopamine signaling during exercise, improving running performance.
- Evidence
- Emerging
- Design
- Animal study
Cite this record: https://thecellwell.org/studies/HH-20099
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