CellWell record HH-19956
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence
Jiang M; Huizenga MCW; Wirt JL; Paloczi J; Amedi A; van den Berg RJBHN; Benz J; Collin L; Deng H; Di X; Driever WF; Florea BI; Grether U; Janssen APA; Hankemeier T; Heitman LH; Lam TW; Mohr F; Pavlovic A; Ruf I; van den Hurk H; Stevens AF; van der Vliet D; van der Wel T; Wittwer MB; van Boeckel CAA; Pacher P; Hohmann AG; van der Stelt M
Nature communications ยท 2023
In plain language
In mice, a peripherally restricted MAGL inhibitor elevated 2-arachidonoylglycerol in peripheral organs, reduced liver injury and chemotherapy pain without brain-mediated side effects.
- Evidence
- Emerging
- Design
- Animal study
Cite this record: https://thecellwell.org/studies/HH-19956
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