CellWell record HH-199387
Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis
Lin H; Ho MYM; Wang B; Mansoori S; Yang Y; Wang W; So PK; Xu A; Yang S; Chang J; Man AMH; Piao H; Gao C; Siu PMF; Li X; Cheng KKY
Nature communications · 2026
In plain language
Branched-chain α-ketoacids impair insulin secretion in pancreatic beta cells by redirecting glucose metabolism through the lactate dehydrogenase A pathway instead of energy production.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-199387
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