CellWell record HH-19931
A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice
Balsevich G; Petrie GN; Heinz DE; Singh A; Aukema RJ; Hunker AC; Vecchiarelli HA; Yau H; Sticht M; Thompson RJ; Lee FS; Zweifel LS; Chelikani PK; Gassen NC; Hill MN
eLife ยท 2023
In plain language
In C385A knock-in mice, the FAAH A/A genotype increased glucocorticoid-induced hyperphagia, weight gain and hypothalamic AMPK activation, amplified ghrelin-driven feeding, and blunted leptin's appetite-suppressing effect via AgRP neurons.
- Evidence
- Emerging
- Design
- Animal study
Cite this record: https://thecellwell.org/studies/HH-19931
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