CellWell record HH-19861
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Krishna Kumar K; Shalev-Benami M; Robertson MJ; Hu H; Banister SD; Hollingsworth SA; Latorraca NR; Kato HE; Hilger D; Maeda S; Weis WI; Farrens DL; Dror RO; Malhotra SV; Kobilka BK; Skiniotis G
Cell ยท 2019
In plain language
Cryo-electron microscopy resolved the structure of the CB1 receptor bound to Gi protein and the potent synthetic agonist MDMB-Fubinaca, showing how the drug increases nucleotide exchange to activate signaling.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-19861
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