CellWell record HH-19468
Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2
Martínez-Torres S; Cutando L; Pastor A; Kato A; Sakimura K; de la Torre R; Valjent E; Maldonado R; Kano M; Ozaita A
Brain, behavior, and immunity · 2019
In plain language
Blocking monoacylglycerol lipase in mice raised 2-AG but triggered cerebellar microglial reactivity and impaired fine motor coordination through cyclooxygenase-2, showing that raising endocannabinoid tone carries brain-region-specific costs.
- Evidence
- Emerging
- Design
- Animal study
- Studied in
- Animal
Cite this record: https://thecellwell.org/studies/HH-19468
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