CellWell record HH-19257
Lithium and the Brain-Bone Axis: A Bridge between Osteoporosis and Alzheimer's Disease
Lee JW, Hasegawa T, Ikedo A et al.
Current Osteoporosis Reports ยท 2026
In plain language
GSK-3 inhibition and beta-catenin stabilization run the same Wnt pathway in osteoblasts and in neurons, so one signaling mechanism reaches both bone-forming cells and brain tissue. This is the shared-substrate argument for why a single ion shows up in two organ systems that are usually studied separately.
- Evidence
- Emerging
- Design
- Expert review
Cite this record: https://thecellwell.org/studies/HH-19257
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