Studies

CellWell record HH-19254

Lithium-induced enhancement of mitochondrial oxidative phosphorylation in human brain tissue

Maurer IC, Schippel P, Volz HP

Bipolar Disorders ยท 2009

In plain language

In human brain tissue, lithium raised respiratory chain complex I+III and II+III activity in a dose-dependent way, peaking at 1 mM. A direct measurement in human tissue that ties lithium to mitochondrial energy production, which is the cellular layer underneath the neuroprotection signal.

Evidence
Emerging
Design
Cell-culture study
Studied in
Human

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