CellWell record HH-19253
Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)
Beurel E, Michalek SM, Jope RS
Trends in Immunology ยท 2010
In plain language
GSK-3 sets the balance between pro-inflammatory and anti-inflammatory cytokine output, and inhibiting it shifts that balance toward the anti-inflammatory side across both innate and adaptive arms. Because lithium is a GSK-3 inhibitor, this is the upstream framework that explains its immune-modulating signal rather than a lithium trial itself.
- Evidence
- Established
- Design
- Expert review
Cite this record: https://thecellwell.org/studies/HH-19253
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