CellWell record HH-19252
Mini review: Recent advances on epigenetic effects of lithium
Marie-Claire C, Etain B, Bellivier F
Neuroscience Letters ยท 2021
In plain language
Lithium acts on three epigenetic layers -- DNA methylation, histone modification and non-coding RNA -- rather than on a single receptor. This is the mechanistic bridge for how a simple ion produces durable changes in gene expression, and it places lithium's methylation activity in the epigenetic machinery rather than in one-carbon nutrient metabolism.
- Evidence
- Emerging
- Design
- Expert review
Cite this record: https://thecellwell.org/studies/HH-19252
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