CellWell record HH-19244
Differential regulation of STAT family members by glycogen synthase kinase-3
Beurel E; Jope RS
The Journal of Biological Chemistry ยท 2008
In plain language
Inhibiting GSK-3, the enzyme lithium blocks, cut interferon-gamma-driven STAT3 activation by more than 75 percent in astrocytes, microglia and macrophages, identifying one route by which lithium can dampen neuroinflammatory signalling.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
- Studied in
- Animal, Cell / in vitro
Cite this record: https://thecellwell.org/studies/HH-19244
Produced by the CellWell Research Engine, custom software owned and operated by CellWell and The Holistic Hub. All rights reserved. This analysis, its indexing and its evidence classifications are proprietary. Any use, republication or onward sharing must credit CellWell Research Engine (thecellwell.org) as the source.
This is an educational research library, not medical advice. Nothing here may be used to diagnose, treat, cure, or prevent any disease. Always consult a qualified professional.