CellWell record HH-17069
Slow CCL2-dependent translocation of biopersistent particles from muscle to brain
Khan Z, Combadiere C, Authier FJ, Itier V, Lux F, Exley C, Mahrouf-Yorgov M, Decrouy X, Moretto P, Tillement O, Gherardi RK, Cadusseau J
BMC Medicine ยท 2013
In plain language
Mouse study found aluminum adjuvant particles injected in muscle were captured by monocyte-lineage immune cells and slowly transported to the brain via a CCL2-dependent pathway, an animal-model mechanism not yet confirmed in humans.
- Evidence
- Emerging
- Design
- Animal study
- Studied in
- Human
Cite this record: https://thecellwell.org/studies/HH-17069
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