Studies

CellWell record HH-168677

The 'Chloride Theory' for Heart Failure Pathophysiology: An Updated Narrative Review 2025

Hajime Kataoka

2026

In plain language

This updated review argues that changes in serum chloride, not just sodium and water, track plasma volume and neurohormonal activity in heart failure and predict loop diuretic resistance.

Evidence
Emerging
Design
Expert review

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