CellWell record HH-163322
Exogenous estradiol modulates entorhinal cortex contributions to episodic encoding of conditioned threat in women
Katelyn I Oliver; Kristina Dahlgren; Alyssa R Roeckner; Cecilia A Hinojosa; Justin L C Santos; Linzie S Taylor; Helena Zeleke; Amy Murphy; Colin Johnson; Dasani DelRosario; Timothy D Ely; Rebecca Hinrichs; Natalie A Merrill; Marisa R Young; Andrea Braden; Abigail Powers; Sanne J H van Rooij; Vasiliki Michopoulos; Jennifer S Stevens
2026
In plain language
In naturally-cycling women with trauma symptoms, transdermal estradiol did not directly improve threat memory recognition, but higher combined estradiol and progesterone reduced entorhinal cortex activity linked to threat encoding.
- Evidence
- Established
- Design
- Randomized controlled trial
Cite this record: https://thecellwell.org/studies/HH-163322
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