Studies

CellWell record HH-154799

Cocoa polyphenols in brain health: BDNF/CREB-mediated mechanisms in depression, cognition, and the gut-brain axis

LePing Li; Henry H Y Tong

2026

In plain language

Cocoa polyphenols mitigated depressive symptoms and enhanced mood via dopaminergic modulation and gut microbiota alterations, but cognitive benefits were inconsistent across human trials despite neuroprotective mechanisms.

Evidence
Emerging
Design
Expert review

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