CellWell record HH-152848
Immunopathophysiology of Gluten-Associated Insulin Resistance: A 33-mer Gliadin -- CXCR3 -- Zonulin Axis Driving IRAK4-Centered Innate Immune Amplification, Sulfur Depletion, and Upstream Modulation by Aspergillus niger Prolyl Endopeptidase
Maher Monir Akl; Abdelrahman Ahya M. Ali; Ahmed Ali. El-Nagar; Amr Ahmed
2026
In plain language
This hypothesis paper proposes that the gliadin 33-mer peptide triggers zonulin release via CXCR3 binding, driving IRAK4-centered innate immune activation and sulfur depletion that could impair insulin signaling and cause insulin resistance.
- Evidence
- Emerging
- Design
- Preprint
Cite this record: https://thecellwell.org/studies/HH-152848
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