CellWell record HH-147809
Uncoupling proximal tubule ammoniagenesis from bicarbonate generation by PCK1 deletion
Hyun-Wook Lee; Rukiye Nar; I David Weiner
2026
In plain language
In mice, proximal-tubule-specific deletion of PEPCK increased urinary ammonium excretion but lowered serum bicarbonate, indicating that ammonium excretion functions as a marker of bicarbonate generation rather than a direct driver of acid-base balance.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-147809
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