Studies

CellWell record HH-14294

The kidney distal tubule potassium switch, modern diet and hypertension.

Welling PA; Delpire E; Ellison DH; Staub O; Stowasser M; Fenton RA

Nature reviews. Nephrology ยท 2026

In plain language

A review describes a kidney distal tubule 'potassium switch,' involving Kir4.1/Kir5.1 channels and WNK kinase signaling, that senses dietary potassium to regulate sodium-chloride cotransporter activity relevant to hypertension.

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