CellWell record HH-134177
Experimental Models of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comparative Analysis of a Choline-Deficient and Cholesterol-Enriched Diet in Rats
Vladimir A Shipelin; Nikita A Petrov; Nikita V Trusov; Yuliya S Sidorova; Yulia M Markova; Zakhar A Chalyy; Anton D Konev; Anastasiya S Balakina
2026
In plain language
In rats, a choline-deficient high-fat-fructose diet produced steatosis with oxidative stress but minimal inflammation, while a cholesterol-enriched version caused inflammation, early fibrosis, and dyslipidemia, modeling distinct MASLD phenotypes.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-134177
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