CellWell record HH-132442
Effect of Carbon-Chain Length in [125I]iodophenyl and [211At]astatophenyl Derivatives on Prostate-Specific Membrane Antigen-Targeted Radioligands
Kazuma Nakashima; Honoka Asahina; Takuma Hasegawa; Hiroyuki Fujimoto; Masashi Murakami; Kazuhiro Ooe; Atsushi Toyoshima; Hiroyuki Watanabe; Masahiro Ono
2026
In plain language
In mice, extending the carbon-chain linker in iodine-125-labeled PSMA radioligands increased blood retention and lowered kidney uptake, improving the tumor-to-kidney ratio compared with the shorter-chain compound.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-132442
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