CellWell record HH-13028
The H2S donor sulforaphane inhibits NLRP3 inflammasome activation by inducing mitochondrial autophagy and mitigating CBS-H2S axis damage in in-vitro and in-vivo models of Parkinson's disease.
Xie W; Wu K; Zhang L; Feng X; Yang S; Jia S; Li Y; Wang X
Bioorganic chemistry ยท 2026
In plain language
In Parkinson's disease models, the H2S donor sulforaphane activated the CBS-H2S axis, promoted mitochondrial autophagy, reduced mitochondrial ROS, and inhibited NLRP3 inflammasome activation, improving motor performance and dopaminergic neuron survival in mice.
- Studied in
- Animal, Cell / in vitro
Cite this record: https://thecellwell.org/studies/HH-13028
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