CellWell record HH-12756
Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain.
Zimmermann S; Mathew A; Bondareva O; Elwakiel A; Waldmann K; Jiang S; Rana R; Singh K; Kohli S; Shahzad K; Biemann R; Roskoden T; Storsberg SD; Mawrin C; Krügel U; Bechmann I; Goldschmidt J; Sheikh BN; Isermann B
Kidney international · 2024
In plain language
Chronic kidney disease disrupted the blood-brain barrier and microglial potassium and calcium homeostasis in mice, activating neuroinflammation linked to cognitive impairment that reversed after kidney transplantation.
- Studied in
- Animal
Cite this record: https://thecellwell.org/studies/HH-12756
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